- 详细信息
- 引用文献
- 技术资料
- 英文名：
hCMEC/D3
- 库存：
99
- 供应商：
武汉普诺赛生命科技有限公司
- 细胞类型：
咨询
- 品系：
咨询
- 组织来源：
女性；成人
- 相关疾病：
脑微血管
- 物种来源：
人类
- 免疫类型：
咨询
- 细胞形态：
纺锤形细胞
- 是否是肿瘤细胞：
转化细胞系
- 器官来源：
脑微血管
- 运输方式：
干冰
- 年限：
咨询
- 生长状态：
贴壁细胞
- 规格：
1×10⁶cells/T25培养瓶
The hCMEC/D3 cell line was derived from human temporal lobe microvessels isolated from tissue excised during surgery for control of epilepsy. The primary isolate was enriched in cerebral endothelial cells (CECs). In the first passage, cells were sequentially immortalized by lentiviral vector transduction with the catalytic subunit of human telomerase (hTERT) and SV40 large T antigen, following which CEC were selectively isolated by limited dilution cloning, and clones were extensively characterized for brain endothelial phenotype. This brain microvascular endothelial cell line represents one such model of the human BBB that can be easily grown and is amenable to cellular and molecular studies on pathological and drug transport mechanisms with relevance to the central nervous system (CNS).
更多关于武汉普诺赛细胞相关查看“武汉普诺赛官网”
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引用文献标题：Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization
doi：10.1038/s41467-025-57146-5
期刊：Nature Communications
IF：14.7
作者：Wang Xing-wang, Ye Cheng-qiang, Tang Qian, Yu Hong-mei, Wang Jing, Fu Guo-sheng, Ren Ke-feng, Yu Lu, Ji Jian
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